Cancer Races

Wednesday, October 1, 2008

Fwd: Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 28, 2008 at 4:45 AM
Subject: Cyclooxygenase-2, multidrug resistance 1, and breast cancer resistance protein gene polymorphisms and inflammatory bowel disease in the Danish population.
To: mesothelioma77@gmail.com

[1]Scand J Gastroenterol. 2008 Sep 26; 1-9
Ostergaard M, Ernst A, Labouriau R, Dagiliene E, Krarup HB, Christensen M, Thorsgaard N, Jacobsen BA, Tage-Jensen U, Overvad K, Autrup H, Andersen V

Objective. Crohn's disease (CD) and ulcerative colitis (UC) are characterized by an impaired mucosal defence to normal constituents of the intestinal flora and a dysregulated inflammatory response. The purpose of the study was to investigate whether single nucleotide polymorphisms (SNPs) in genes involved in these processes were associated with CD and UC. Material and methods. Allele frequencies of the cyclooxygenase 2 (COX-2/PTGS2/PGHS2) G-765C and breast cancer resistance protein (BCRP/ABCG2) C421A as well as allele and haplotype frequencies of multidrug resistance 1 (MDR1, ABCB1) SNPs G2677T/A, C3435T and G-rs3789243-A (intron 3) were assessed in a Danish case-control study comprising 373 CD and 541 UC patients and 796 healthy controls. Results. Carriers of the homozygous COX-2 and MDR1 intron 3 variant had a relatively high risk of CD, odds ratio (95% CI) (OR (95% CI))=2.86 ((1.34-5.88) p=0.006) and 1.39 ((0.99-1.92) p=0.054), respectively, and for UC of 2.63 ((1.33-5.26) p=0.005) and 1.28 ((0.96-1.51) p=0.093), respectively, assuming complete dominance. No association was found for BCRP or other MDR1 SNPs, or for selected MDR1 haplotypes. No effect-modification of smoking habit at the time of diagnosis was found. Conclusions. An effect of the COX-2 polymorphism on both CD and UC was shown which is compatible with the presence of a recessive allele in linkage equilibrium with the SNP marker in the COX-2 gene. The polymorphism located in intron 3 of the MDR1 gene showed a weak association with CD, and a marginally suggestive association with UC.

___
Source: http://www.hubmed.org/display.cgi?uids=18819034
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc

Take away all your financial problems and….

LIVE THE LIFE YOU WANT!!! Have Some fun and Enjoy What life has to Offer...

Below are more links and sites where you can join and or get more info on Finance and Humor and Funny Stuffs. These are really going to make your day a good one.

Here are some site and links you may need to go to in case you need more info and join the fun with social networking sites.

More Links and Info Sites For Your Searches

Search Info Source

Humor and Funny Stuffs

Funny Tagalog Quotes, Funny Short Skits, Funny Car Commercials

I Need Some Funny Jokes Riddles For Teenagers, Really Funny Quick Jokes

Funny Goodbye Letters, Funny Rude Free Ecards, Funny Sick Twisted Humor

Funny Videos and Entertainment

Funny Videos

Your Online Social Utility Networking Site Links. Join The Many who have enjoyed Staying Connected with Friends, Classmates, Coworkers, and People Around the, and the rest of the world.

More Financial Info Links

Life Insurance, Term Life Insurance, Life Insurance Quotes, Life Insurance Companies, Life Insurance UK, Over 50s Life Insurance, Tesco Life Insurance UK, Life Insurance Quote, Cheap Life Insurance In UK, How Does Life Insurance Works, How Much Does Life Insurance Cost, What Is The Average Price Of Life Insurance , Statistics Disability Insurance, Calculate A Mortgage, Mortgage Calculator UK, Student Loans, Mortgage, Motor Insurance Gravesend, Understanding Automobile Insurance, Mortgage Refinance In Ontario Canada, Car Insurance, What Is The Average Price of Life Insurance, How Much Does Life Insurance Cost

Thanks very much,

Lorenz

I hope you like what we have posted here. Especially the links that we have provided for you searches and more information and guide on what is funny and humorous, you financial info needs and online social utility networking site that can help you keep in touch with friends, classmates, coworkers and people around them.

A freshen Day can lead to a better feeling.

You Have A Wonderful and Full of Humor and Funny Stuffs

A Better Feeling can make so Enjoyable and Fun Especially with a Family Man.

So, Get some Fun!

Thanks,

Lorenz

Fwd: Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sun, Sep 28, 2008 at 4:45 AM
Subject: Hsp72 chaperone function is dispensable for protection against stress-induced apoptosis.
To: mesothelioma77@gmail.com

[1]Cell Stress Chaperones. 2008 Sep 26;
Chow AM, Steel R, Anderson RL

In addition to its role as a molecular chaperone, heat shock protein 72 (Hsp72) protects cells against a wide range of apoptosis inducing stresses. However, it is unclear if these two roles are functionally related or whether Hsp72 inhibits apoptosis by a mechanism independent of chaperone activity. The N-terminal adenosine triphosphatase domain, substrate-binding domain and the C-terminal EEVD regulatory motif of Hsp72 are all essential for chaperone activity. In this study, we show that Hsp72 mutants with a functional substrate-binding domain but lacking chaperone activity retain their ability to protect cells against apoptosis induced by heat and tumor necrosis factor alpha. In contrast, a deletion mutant lacking a functional substrate-binding domain has no protective capacity. The ability of the Hsp72 substrate-binding domain to inhibit apoptosis independent of the regulatory effects of the adenosine triphosphate-binding domain indicates that the inhibition of apoptosis may involve a stable binding interaction with a regulatory substrate rather than Hsp72 chaperone activity.

___
Source: http://www.hubmed.org/display.cgi?uids=18819021
--
~
Powered by [5]RssFwd, a service of [6]Blue Sky Factory, Inc