Fwd: Clinical characteristics of small cell carcinoma of the breast.

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From: HubMed - breast cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 22, 2008 at 1:20 PM
Subject: Clinical characteristics of small cell carcinoma of the breast.
To: mesothelioma77@gmail.com


[1]Oncol Rep. 2008 Apr; 19(4): 981-5
Sadanaga N, Okada S, Shiotani S, Morita M, Kakeji Y, Kitamura K, Tamiya S, Sugimachi K, Maehara Y

Primary small cell carcinoma of the breast is a rare tumor of which less than 40 cases have been reported in the literature. Because of its rarity, its biological and clinical characteristics are still not fully understood and, to date, no standard therapy has been developed. Here, we present a case and a review of the literature regarding this cancer, focusing on clinicopathological findings and treatment. Primary small cell carcinoma of the breast differs from more common types of breast cancer in its biological features. It is anticipated that an improved understanding of the clinical characteristics of this tumor will result in the development of new therapeutic modalities, which would improve its prognosis.



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Source: http://www.hubmed.org/display.cgi?uids=18357385
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Fwd: Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription.

---------- Forwarded message ----------
From: HubMed - cancer <rssfwd@rssfwd.com>
Date: Sat, Mar 22, 2008 at 1:20 PM
Subject: Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription.
To: mesothelioma77@gmail.com


[1]Chembiochem. 2008 Mar 20;
Hosoya T, Arai MA, Koyano T, Kowithayakorn T, Ishibashi M

The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors. To search for Hh/GLI inhibitors, we screened for naturally occurring inhibitors of the transcriptional activator GLI1 by using a cell-based assay. We identified zerumbone (1), zerumbone epoxide (2), staurosporinone (9), 6-hydroxystaurosporinone (10), arcyriaflavin C (11) and 5,6-dihydroxyarcyriaflavin A (12) as inhibitors of GLI-mediated transcription. In addition, we isolated physalins F (17) and B (18) from Physalis minima, which are also potent inhibitors. These compounds also inhibited GLI2-mediated transactivation. Semiquantitative RT-PCR and Western blotting analysis further revealed that 1, 9, 17, and 18 decreased Hh-related component expressions. We also show that inhibitors of GLI-mediated transactivation reduce the level of the antiapoptosis Bcl2 expression. Finally, these identified compounds were cytotoxic to PANC1 pancreatic cancer cells, which express Hh/GLI components. These results strongly suggest that the cytotoxicity of the compounds to PANC1 cells correlates with their inhibition of GLI-mediated transcription.



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Source: http://www.hubmed.org/display.cgi?uids=18357592
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